Description: Isoflavanone derivatives have been identified as a new class of aromatase inhibitors and showed anti-proliferative effects on human breast cancer cells in our previous study. Specifically, isoflavanones bearing an Î±-heteroaryl functionality demonstrated enhanced binding affinity with the enzyme active site. In this project, we will synthesize isoflavanone compounds by incorporating heteroaryl functional groups on the scaffold. Microwave-assisted organic reactions will be investigated to optimize reaction conditions, and NMR techniques will be used to study the reaction mechanisms. The synthesized compounds will be tested for their potential anticancer activities in fluorescence enzyme assays in follow up projects. It is expected that 20 hours/week on this project.
Timeline: week 1-2, training; week 3-6, explore synthesize isoflavanone compounds; week 7-8, wrap up and write research report.
Expected outcomes: learn laboratory techniques, think critically and analyze logically, sharpen presentation and writing skills, and develop enthusiasm for scientific research.
Necessary Skills: Basic Computer Skills
Preferred Skills: Basic laboratory skills
Project URL: faculty_research.html
|Dr. Lili Ma||Chemistryemail@example.com|
Description: The Guy lab seeks to understand how the cell forms chemical modifications on transfer RNA (tRNA) and the role that these modifications play for proper protein translation and healthy cell growth. Two important tRNA modifications are methylations that occurs on nucleotides 32 and 34 on several tRNAs in organisms ranging from yeast to humans. These modifications are formed by the activity of two protein complexes. The protein complex that methylates nucleotide 32 is composed of Trm7 and Trm732, and that which methylates nucleotide 34 is composed of Trm7 and Trm734. Although yeast cells lacking only the TRM732 gene or only the TRM734 gene do not have an obvious growth defects, data indicate that lack of these modifications in humans are associated with type 2 diabetes, polycystic ovary syndrome, benign tumors called thyroid adenomas, and defects in avoiding viral infections.
We are using budding yeast as a model system to understand the role of methylation at positions 32 and 34 in the cell to better understand the link between TRM732 and TRM734 with these human diseases.
The UR-STEM student performing this research will test the growth phenotypes of yeast strains which lack TRM732 and TRM734 in combination with other genes previously identified to interact with these proteins, or with other genes identified by the student through online database searches. If defects are discovered, the student will seek to identify which tRNA lacking the methylation at nucleotide 32 or 34 is causing the defect.
The student will learn basic laboratory techniques including yeast cell culture, polymerase chain reaction (PCR), yeast and bacterial transformation, growth assays, rudimentary bioinformatics, and data analysis. It is expected that the student will work 20 hours a week for 8 weeks over the summer, and will be paid $1400 for the research. At the end of the summer, the student will have tested several yeast strains and identified tRNAs that must be methylated by the Trm7-Trm732 and Trm7-Trm734 protein complexes for proper function. The student is expected to attend at least two seminars held during the summer, and to participate in the Heather Bullen Summer Celebration of Student Research. The student will be guided and helped throughout the research by Dr. Guy and by other members of the Guy lab.
|Dr. Michael Guy||Chemistryfirstname.lastname@example.org|
|Dr. Patrick Hare||Chemistryemail@example.com|
Description: Students will perform experiments in the exciting field of annulene and calixarene chemistry. These compounds are important for their potential applications ranging from energy storage to nuclear waste treatment, from sensors to organic light emitting diodes. Students participating will get hand-on experience synthesizing, purifying and characterizing new organic compounds that can be integrated with compounds prepared by other students to create a variety of annulene-calixarene hybrids. This is a continuing project where each student will have a rewarding experience.
Students will be trained in all of the techniques necessary to conduct the research and will learn to keep an electronic lab notebook and present their work through a research poster.
|Dr. KC Russell||Chemistryfirstname.lastname@example.org|
Description: The goal of this research is to characterize a set of methacrylate-based PPMs in efforts to understand the fundamental mechanisms that underlie the behavior and interactions of the PPMs with analytes that are recognized as common pollutants. Sterics, charge, and mass are some of the properties that will be investigated as interactions are monitored via Capillary Electrochromatography (CE). Understanding these fundamental properties are important when designing and engineering materials that could aid or support in designing materials with potential environmental, electrical, and medical uses. The results of this investigation will reveal information about how to best engineer materials to the best of current scientific knowledge.
(1) Initial Synthesis and Characterization of Acrylate and Methacrylate Porous Polymer Monoliths
The goal of this project was to synthesize and characterize porous polymer monoliths (PPMs) made from various acrylates and methacrylates. Attributes of the PPMs will be investigated via CE. The relationships between the inner diameter of capillary, crosslinker, porogen, temperature, and analyte concentration will be explored. An alkyl benzene series (toluene through 1-phenyl octane) will be used to characterize the PPMs over the range of 25°C to 60°C in 5°C increments, and mobile phase concentration of 75% acetonitrile:25% Tris base.
(2) Spectroscopic Analysis of Tunable, Stimuli Responsive Polymeric Materials
Tunable, stimuli responsive polymeric materials are interesting due to their viability and usage in so many different fields. Engineering these materials can lead to revolutions in environmental, medical, and electrical applications, to name a few. Understanding the fundamentals of how these materials behave and interact with analytes is important. By creating polymeric monoliths that can be used as stationary phases, chromatography can reveal mechanisms by which molecules interact with them. Monoliths can be altered through reaction conditions, porogens, monomers, crosslinkers, etc. Small changes in monolith solutions may result in dramatically different structures. A variety of different acrylate and methacrylate porous polymer monoliths will be synthesized in fused silica capillary columns with some of the aforementioned modifications. Cross-sections of polymers will be coated with gold and imaged using secondary electron Scanning Electron Microscopy in order to provide morphology information. NMR and IR spectroscopy may be performed to gather more information about the structure of the PPMs. The results of these studies could provide insights for understanding the structure-function relationship tunable, stimuli responsive materials.
Required Skills: Pre-Requisite Courses: General Chemistry I/II, Organic Chemistry I/II (Project 2)
Desirable Skills: Likes engineering projects (electronics, building, creating models,etc.; Project 1), has experience with spectrometry (IR, NMR, UV/Vis; Project 2), some synthesis experience (teaching lab experience is fine; Project 2)
Description: In recent times, there has been tremendous advancement in Wireless Local Area Network (WLAN) Technology. Wireless networks have become the defacto communication method used by most people due to their ubiquitous nature. 802.11AC is one of current wireless communication technologies deployed by most organizations. It provides high bandwidth compared to its predecessors (802.11a/b/g/n). VoIP has been a telephony technology of choice by most organizations and individuals. Since most individuals use WLANs for VoIP related calls, it is important to evaluate the extent to which QoS is impacted when VoIP applications are used in WLANs under different networking conditions.
In this project, we would study the performance of VoIP applications in 802.11ac networks under different networking conditions.
|Anthony Tsetse||Computer Scienceemail@example.com|
|Yi Hu||Computer Sciencefirstname.lastname@example.org|
|Wei Hao||Computer Scienceemail@example.com|
Skills: Applicants should either have (a) the equivalent of an STA 213 background OR (b) be majoring in mathematics or statistics and have taken at least one STA course within the major. Some computing skills (e.g. finding things on the internet, using EXCEL) are strongly preferred.
Project URL: https://sappho.nku.edu/~nolanj1/SIS.htm
Skills: Some background in statistics would be helpful. Students should have good computer skills. Some programming experience is preferred, but not necessary.
Skills: The student should be able to use image-processing software (such as MS Paint, ImageJ, Photoshop, etc.) to pre-process images (changing to grayscale, creating rotations, and standardizing size). Further, the student should have some computer programming skills.
The student will work in a linux-based environment and will be taught to use the Caffe software to train neural networks. Knowledge of the linux environment and scripting is a bonus.
Project URL: https://mathstat.nku.edu/hab
|Dr. Michael Waters||Mathematics & Statisticsfirstname.lastname@example.org|
Description: Students are invited to participate in the characterization of superconducting devices. This characterization consists of low-temperature measurements of the superconducting properties of films and devices such as finding the critical temperature, critical current, and critical magnetic field of these dives, etc.
The students will learn the use of cryogenic liquids, perform measurements at low pressures, measure voltages and currents, learn the basics of programming for data acquisition, and also learn the basics of photolithography to fabricate electronic circuits, etc.
Students will collaborate in ongoing projects on the fabrication of Josephson oscillators, electromagnetic signal detectors, Qubits and fault current limiters.
Skills: The willingness to learn problem-solving techniques as to apply to physics experimentation.
Project URL: www.nanojunctions.com
Required skills: experience using Message Passing Interface (MPI) and knowledge of C or C++ programming language.
Helpful (but not necessary) skills: coursework in introductory physics, introductory chemistry, and linear algebra.
Required skills: familiarity with computers and 1 semester of chemistry;
Preferred course experience: PHY 222 or PHY 213.
Required Skills: Interest in astronomy and the night sky. A student with good problem solving skills. Comfort with working with delicate equipment . Basic computer skills including using Excel. Math skills up through at least trigonometry. A willingness to learn some computer programing
Preferred Skills: Student who has taken a computer programming class. A student who has taken a class which includes some optics. A student who has taken or understands basic statistics. Willingness to work at night.
|Dr. Nathan De Lee||Physics, Geology, & Engineering Technologyemail@example.com|